Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion.

By B. Vozarova, C. Weyer, K. Hanson, P. Tataranni, C. Bogardus, R. Pratley. Obesity Research, 2001

673 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b963b728e7b7d0b270c9b0500434c7b157c799bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Haiming Cao
2. B. K. Pedersen
3. P. Trayhurn
4. I. Wood
5. C. Fischer
6. J. Bastard
7. Philippe Froguel
8. Kassem Makki

In Molecular Biology

1. P. Trayhurn
2. Haiming Cao
3. Philippe Froguel
4. Kassem Makki
5. P. Ferré
6. C. Fischer
7. B. K. Pedersen
8. I. Wood

In Oncology

1. Haiming Cao
2. B. K. Pedersen

Citations in the corpus

• Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. (2002, background): “A recent study suggested that the relationship between circulating IL-6 and insulin action was mediated through adiposity (27).”
• Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines (2013, positive): “Similarly to TNF-α, WAT and plasma IL-6 expression correlate with increased body mass, waist circumference, and free fatty acid levels [30], with reduction in circulating IL-6 following weight loss [31].”
• Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Thus, a better understanding of the molecular mechanisms underlying insulin resistance will be required to combat the epidemics of T2DM and cardiovascular disease that are fueled by obesity-associated insulin resistance.”
• IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. (2003, background): “A number of epidemiological studies have shown increased levels of both TNF- and IL-6 in aging (4), in obese individuals (2), and in patients with type 2 diabetes (13, 17, 24, 34).”
• Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, neutral): “Hence, genetic diversity might have contributed, simultaneously, to defense against infection and to the lower prevalence of insulin resistance and type 2 diabetes mellitus among Europeans—and to its increased prevalence among Pima Indians (15).”
• The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. (2004, background): “Interleukin-6 (IL-6) is also secreted by adipocytes, and its concentrations have been positively related to adiposity and negatively related to insulin action (46,47).”
• Adipokines: inflammation and the pleiotropic role of white adipose tissue (2004, background): “Both plasma levels of IL-6 and expression in WAT are elevated in obesity and insulin resistance (Mohamed-Ali et al. 1997; Bastard et al. 2000; Vozarova et al. 2001).”
• Adipocytokines in Obesity and Metabolic Disease (2014, positive): “In patient studies, increased serum IL6 correlates with obesity and insulin resistance (Vozarova et al. 2001, Bastard et al. 2002, Spranger et al. 2003).”