Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.

By K. Hotary, E. Allen, P. Brooks, N. Datta, M. Long, S. Weiss. Cell, 2003

666 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b961909b76d505a74103d0d5876982793bf474b3

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Citations in the corpus

Matrix metalloproteinases and tumor metastasis (2006, background): “This membranetethered MMP serves as the major cell-associated collagenase that confers normal and neoplastic cells with invasive activity [135, 136].”
Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets (2012, background): “Interestingly, MMP14, a membrane type metalloproteinase, is particularly efficient in hydrolyzing basement membranes (30, 31), and its expression can be induced by SNAI in carcinomas (30).”
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion (2007, background): “and the inability of cells to invade complex 3D extracellular matrice”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, neutral): “After leaving the tumour microenvironment, motile tumour cells encounter the architecturally complex extracellular matrix (ECM), which is rich in collagen I and fibronecti”
Control of matrix metalloproteinase catalytic activity. (2007, background): “Despite the largely disappointing clinical trials, several studies in mice and cell models have convincingly demonstrated that specific MMPs are indeed essential mediators of tumor progression and invasion (Coussens et al., 2002; Hotary et al., 2003; Hotary et al., 2002; Wilson et al., 1997).”
Three-Dimensional Cell Culture Matrices: State of the Art (2008, background): “(C) Membrane type-1-MMP-transfected cells proliferated at a significantly faster rate than control cells under a 3D collagen gel growth environment.(132) (D) Alginate-encapsulated mouse oocytes (left) and in vivo-like follicle development after 8 days of culture (right).”
Matrix metalloproteinases. (2010, background): “However, the authors found that the overproduction of a number of soluble MMPs did not have an effect on tumour cell growth [135].”
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited (2009, background): “…MMP inhibitors, and the 3D cancer cell invasion program To recreate an in vivo–like environment for migrating cancer cells, multicellular spheroids of HT-1080 fibrosarcoma cells were embedded within 3D gels of native type I collagen (Hotary et al., 2003; Sabeh et al., 2004; Li et al., 2008).”
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (2008, background): “MT1-MMP plays a crucial role in degrading extracellular matrix and allows tumor cells to escape the matrix-enforced growth control effect (Hotary et al., 2003).”
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP (2004, methodology): “…of Michigan, Ann Arbor, MI), MDA-MB-231 breast carcinoma cells (American Type Culture Collection), PANC-1 pancreatic carcinoma cells (American Type Culture Collection), and DU-145 carcinoma cells (American Type Culture Collection) were cultured as described previously (Hotary et al., 2003).”