Oct‐4: Gatekeeper in the Beginnings of Mammalian Development

By M. Pesce, Hans Robert Schöler. Stem Cells, 2001

829 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b93f6bd68372435f32650f45d1e5245be1eb10a0

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Citations in the corpus

Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells (2005, background): “Therefore, elucidating the mechanisms behind the transcriptional regulation of Pou5f1 is of considerable interest (33).”
Competing interests (2010, neutral): “Techniques such as immunocytochemistry, fluorescence microscopy, polymerase chain reaction, and RNA in situ hybridization are generally used to measure the expression of stage-specific embryonic antigen-1, and POU family transcription factors Oct4/Oct-3 [8], and CD9 [9] for undifferentiated state of”
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst (2005, background): “Blastomeres acquire apicobasal polarity typified by apical localization of microvilli and acquisition of cytoplasmic polarity (Fleming et al., 2001; Pratt et al., 1982; Reeve and Ziomek, 1981).”
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. (2003, background): “Oct4 is restricted to pluripotent and germ line cells (Pesce and Schöler, 2001), but forced constitutive expression of Oct4 is not sufficient to prevent ES cell differentiation (Niwa et al.”
Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. (2006, background): “Accordingly, CD24 CD133 PEC expressed high levels of the SC-specific (32,33) transcription factors BmI-1 (Figure 3D) and Oct-4 (Figure 3E).”
Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. (2004, background): “Subsequent studies seemed to suggest that Oct4 might be a specific gene marker for totipotency or a gene required for imposing totipotency ( 6-8 ).”
Core transcriptional regulatory circuitry in human embryonic stem cells. (2005, background): “OCT4 is known to interact with other transcription factors to activate and repress gene expression in mouse ES cells (Pesce and Schöler, 2001).”