Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer.

By E. Rosivatz, I. Becker, K. Specht, E. Fricke, B. Luber, R. Busch, H. Höfler, K. Becker. American Journal of Pathology, 2002

608 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b8e6eb2be6c38f00ec73ff5de6fd0dbb0a1c6063

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Citations in the corpus

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. (2008, background): “ZEB2 is up-regulated in advanced stages of ovarian, gastric, and pancreatic cancer (Rosivatz et al. 2002; Elloul et al. 2005, 2006; Imamichi et al. 2007), and serves as a prognostic marker for squamous cell carcinoma (Maeda et al. 2005).”
The Snail genes as inducers of cell movement and survival: implications in development and cancer (2005, background): “The analyses of biopsies obtained from breast tumours (Blanco et al., 2002; Elloul et al., 2005); gastric cancers (Rosivatz et al., 2002); hepatocellular carcinomas (Sugimachi et al., 2003; Miyoshi et al., 2005); colon cancers (Palmer et al., 2004) and synovial sarcomas (Saito et al., 2004) have…”
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. (2008, background): “Over 90% of these tumors do not express E-cadherin and exhibit a permanent EMT phenotype (Rosivatz et al., 2002; Yang et al., 2004).”
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, unknown): “The examples cited as evidence of EMT in clinical neoplasms—including scattered single cell infiltration by lobular carcinomas of the breast (171) or diffuse carcinomas of the stomach (182), spindle cell differentiation in squamous carcinomas, and blending of sheets of carcinomatous cells into a hig”
The role of epithelial-mesenchymal transition in cancer pathology. (2007, background): “The Ecadherin dependent reduction of cell-cell adhesion in these tumours underlies the extensive permeation of carcinoma cells through interstitial tissues, so producing the characteristic diffusely infiltrating growth pattern seen in histological sections.(59) Most lobular carcinomas of the breast ”
Cadherin switching (2008, background): “In addition, overexpression of Twist has been reported in gastric cancer cells that have abnormally high N-cadherin levels (Rosivatz et al., 2002), and a recent study by Heimark and co-workers showed that Twist binds to an E-box in the first intron of the human N-cadherin gene to upregulate its…”
Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. (2010, background): “The same type of duality has been observed in tumors and cancer cell lines (Hsu et al. 1996; Hazan et al. 1997; Sandig et al. 1997; Tomita et al. 2000; Rosivatz et al. 2002; Gravdal et al. 2007).”
Snail blocks the cell cycle and confers resistance to cell death. (2004, background): “2002), gastric cancer (Rosivatz et al. 2002), and hepatocellular carcinomas (Sugimachi et al.”
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition (2004, result): “These results are consistent with a previous finding that the expression of Snail is found in biopsies that associate with malignant phenotypes from patients with ductal breast cancer, gastric cancer and hepatocellular carcinom”
Epithelial-mesenchymal plasticity in cancer progression and metastasis (2019, background): “data analysis and experimental tumor models, ZEB2 has been shown to have opposing functions in different cancer types, where it is associated with metastasis in ovarian, gastric and pancreatic tumors (Elloul et al., 2005; Imamichi et al., 2006; Rosivatz et al., 2002), but reduces aggressiveness in m”