The role of epithelial-mesenchymal transition in cancer pathology.

By M. Guarino, B. Rubino, G. Ballabio. Pathology (Sydney), 2007

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Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “In practice, the architecture of the invasive front of a non diffuse carcinoma is characterized by individual cells that are detached from the main tumour mass, are less differentiated, less cohesive and appear in tight connection with the surrounding stroma [[143] and Fig.”
Fibroblast heterogeneity in the cancer wound (2014, background): “Another important consequence of CAF-mediated signaling on neoplastic cells is EMT, which is considered a critical process in the extravasation of tumors (Guarino et al., 2007).”
Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response and Dormancy in Hepatocellular Carcinoma Cells (2011, background): “However, at secondary sites, tumor cells are primarily detected by their epithelial characteristics and outgrowing metastases recapitulate the epithelial phenotype of the primary tumor.(34) Despite our increasing understanding of the regulation of epithelial-to-mesenchymal transition, the reverse pr”