Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

By D. Clancy, D. Gems, L. Harshman, S. Oldham, Hugo Stocker, E. Hafen, S. Leevers, L. Partridge. Science, 2001

1,463 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/b8b58878ec8167ceab621eebaf1af0e16a607299

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. Richard I. Morimoto
3. Douglas C. Wallace
4. Linda Partridge
5. L. Guarente
6. G. Lithgow
7. Rute Martins
8. W. Link

In Endocrine and Autonomic Systems

1. T. Blackwell
2. G. Lithgow
3. Rute Martins
4. W. Link
5. Richard I. Morimoto
6. D. Bohmann
7. Gerasimos P. Sykiotis
8. L. Guarente

In Physiology

1. C. Kenyon
2. L. Guarente
3. Linda Partridge
4. G. Lithgow
5. Rute Martins
6. W. Link
7. Douglas C. Wallace
8. Richard I. Morimoto

Citations in the corpus

• Body size, energy metabolism and lifespan (2005, background): “…(Kenyon et al., 1993; Dorman et al., 1995; Ebert et al., 1996; Murakami and Johnson, 1996), Drosophila (Lin et al., 1998; Tatar et al., 2001; Clancy et al., 2001a; Aigaki et al., 2002, 2003) and the mouse (Migliacco et al., 1999; Bluher et al., 2003; Liang et al., 2003) has revolutionised…”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “In addition, mutations in chico, a downstream insulin receptor substrate (IRS)-like signaling protein, increase life span by w40% (Clancy et al., 2001; Tu et al., 2002a).”
• Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. (2009, background): “Similarly, ablation of chico (Irs1-like gene) also increases the life span (190).”
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “The chico (small boy) dwarf mutant of Drosophila has a defect in an insulin-like growth factor receptor substrate protein and an increased life span (36).”
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “…found significant parallels in the regulation of FoxO between Hydra and bilaterian animals, showing that FoxO transcriptional activity is negatively modulated by the PI3K/AKT/SGK pathway and, accordingly, nuclear localization of a FoxO-GFP fusion protein is significantly increased by a PI3K…”
• Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. (2008, background): “Although the basis for this sex difference is presently unknown, sexually dimorphic genetic effects on Drosophila lifespan are not uncommonly reported, for example in the case of chico (Clancy et al., 2001; Tu et al., 2002).”