Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

By M. Forman, John Q. Trojanowski, V. Lee. Nature Medicine, 2004

724 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b893d607200fb51c62d045d6bae401b381ed94c9

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Citations in the corpus

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015, background): “…of these diseases have known causes that involve mutations in ubiquitously expressed proteins 134 , but they follow stereotyped patterns of degeneration that selectively affect certain cell subsets more severely, resulting in disease-specific spatial and temporal patterns of degeneration 135–137 .”
Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations (2007, background): “This sort of accumulation of insoluble, misfolded proteins in neurons is a common feature of many neurodegenerative disorders and has been speculated to cause cellular dysfunction by interfering with essential processes such as intracellular transport.(28) Furthermore, cells that contain TDP-43–posi”
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. (2019, background): “It is likely that separate and combinatory processes of initiation via nasal and/or gastric routes and spread contribute to PD and DLB, and in some patients, there may be a dual hit (Hawkes et al., 2007).”
Stress granules as crucibles of ALS pathogenesis (2013, background): “Like several other neurodegenerative diseases, the degenerating neurons of ALS patients are characterized by the accumulation of protein aggregates (Forman et al., 2004).”
Identification of pre-clinical Alzheimer’s disease by a profile of pathogenic proteins in neurally-derived blood exosomes: a case-control study (2014, background): “008 side and on the surface of neurons [1,2].”
Traumatic brain injury: a disease process, not an event. (2010, background): “Ab plaques and neurofibrillary tangles comprised of tau protein are pathological characteristics of AD (Braak and Braak, 1991; Forman et al., 2004).”
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders (2007, background): “Tau-mediated neurodegeneration As described above, in AD and related neurodegenerative disorders that are collectively referred to as tauopathies”
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007, background): “…neurodegenera- tion raises the possibility of developing a class of therapeutic interventions that treat a variety of neurological disorders by activating the body’s own defenses against age-related dete- rioration and cell death (Bossy-Wetzel et al, 2004; Forman et al, 2004; Selkoe, 2004).”