Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

By Neelroop Parikshak, Michael Jeffrey Gandal, Daniel H. Geschwind. Nature reviews genetics, 2015

392 citations recorded by the source corpus.

Genetic and genomic approaches have implicated hundreds of genetic loci in neurodevelopmental disorders and neurodegeneration, but mechanistic understanding continues to lag behind the pace of gene discovery. Understanding the role of specific genetic variants in the brain involves dissecting a functional hierarchy that encompasses molecular pathways, diverse cell types, neural circuits and, ultimately, cognition and behaviour. With a focus on transcriptomics, this Review discusses how high-throughput molecular, integrative and network approaches inform disease biology by placing human genetics in a molecular systems and neurobiological context. We provide a framework for interpreting network biology studies and leveraging big genomics data sets in neurobiology.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9c9561d5fab2f27aa9cb0d535cafdc69cee17806

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. H. Won
2. Mark Gerstein
3. Michael Jeffrey Gandal
4. Daniel H. Geschwind
5. Andrew E. Jaffe
6. S. Mazmanian

In Molecular Biology

1. T. Sampson
2. H. Won
3. Michael Jeffrey Gandal
4. Mark Gerstein
5. Yucheng T. Yang
6. Lilia M. Iakoucheva
7. Daniel H. Geschwind
8. Kevin P. White

Citations in the corpus

• The Central Nervous System and the Gut Microbiome (2016, background): “Neurodevelopmental disorders are classically studied from a genetic perspective (Parikshak et al., 2015; de la Torre-Ubieta CELL et al., 2016).”
• Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder (2018, positive): “S12), facilitating computational deconvolution of cell type–specific signatures (14, 49, 51).”