Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments

By Benjamin N. Gantner, Randi M. Simmons, D. Underhill. EMBO Journal, 2005

661 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b7e7c8bdbf50216e39cfe1f220dc4a8c4e73f471

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Mihai G. Netea
2. Gordon D. Brown
3. N. Gow
4. C. Munro
5. Shizuo Akira
6. L. Romani

In Molecular Biology

1. Gordon D. Brown
2. S. Gordon
3. D. Chaplin
4. Shizuo Akira
5. C. A. Dinarello
6. Taro Kawai

In Plant Science

1. Gordon D. Brown
2. Mihai G. Netea
3. N. Gow
4. C. Munro

Citations in the corpus

• Soluble Dectin-1 as a tool to detect β-glucans (2006, background): “Higher levels of binding were detected with zymosan than with the live yeast, reflecting the different availability of βglucans on the surface of these particles (Gantner et al., 2005).”
• Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. (2006, background): “In addition, the recognition of yeasts, but not hyphae, by dectin-1 has been proposed to represent an escape mechanism of the fungus (31).”
• Dectin-1: a signalling non-TLR pattern-recognition receptor (2006, background): “Although the β-glucans were traditionally thought to be buried under a layer of glycosylated mannoproteins in fungi, the ability of dectin-1 to recognize these organisms, in a β-glucan-dependent manner, indicates that the carbohydrates are exposed on the fungal cell surface, although possibly restri”
• Overview of the Immune Response (2003, background): “Dectin-1 is a transmembrane receptor that is activated when it binds b-glucans that are major components of the cell walls of yeast.(89) The 3 major collectins in human subjects, mannan-binding lectin (MBL) and surfactant proteins A and D, are all expressed at substantial levels in the human airway ”
• Dectin-1 is required for β-glucan recognition and control of fungal infection (2006, background): “Subsequent evidence has suggested that this model may be too simplistic and that other PAMPs, particularly β-glucans, are exposed on the cell surface and therefore are potentially important in immune recognitio”
• Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans (2007, background): “Studies have suggested that dectin-1 is involved in the recognition of and host defense mechanisms against pathogenic fungi, including Candia albicans and Pneumocyctis carinii , because those fungi express β-glucans in their cell walls and cause cytokine production after infectio”