Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

By T. Kang, T. Yevsa, N. Woller, L. Hoenicke, T. Wuestefeld, D. Dauch, Anja Hohmeyer, M. Gereke, Ramona Rudalska, Anna Potapova and 15 more. Nature, 2011

1,493 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/b776ba8fefb9e3d4783539b5a614d4945e445218

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Campisi
2. A. Mantovani
3. A. Sica
4. Jesús Gil
5. M. Demaria
6. J. Kirkland
7. D. Baker
8. Manuel Serrano

In Physiology

1. Jesús Gil
2. J. Campisi
3. M. Demaria
4. J. Kirkland
5. Manuel Serrano
6. Domhnall McHugh
7. Nicolás Herranz
8. P. Jat

Citations in the corpus

• Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies (2020, background): “These cells clear senescent premalignant cells, thereby protecting premalignant liver from cancer development (535, 536).”
• Macrophage plasticity and polarization: in vivo veritas. (2012, positive): “Th1-driven macrophage activation was found to mediate elimination of senescent hepatocytes, which drive subsequent carcinogenesis (85).”
• The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “SASP-mediated recruitment of macrophages, natural killer cells, neutrophils and T cells is considered beneficial for limiting tumorigenesis 173 and removing apoptotic cells and cell debris to initiate tissue remodelling 174 .”
• Mechanisms and functions of cellular senescence. (2018, positive): “Indeed, during cancer initiation, SASP-dependent recruitment of Th1 cells, NK cells, and macrophages is essential to clear incipient preneoplastic cells and prevent the progression of hepatocellular carcinoma (HCC) (21, 72).”