MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

By J. Martina, Yong Chen, Marjan Gucek, R. Puertollano. Autophagy, 2012

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Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “One study showed that the mTOR–S6K1 pathway activates the regulatory element tripartite motif-containing protein-24 (TIF1A, also known as TRIM24), which promotes its interaction with Pol I and the expression of rRNA (Mayer et al., 2004).”
mTOR Signaling in Growth, Metabolism, and Disease. (2017, background): “mTORC1 also regulates autophagy in part by phosphorylating and inhibiting the nuclear translocation of the transcription factor TFEB, which drives the expression of genes for lysosomal biogenesis and the autophagy machinery (Martina et al., 2012; Roçzniak-Ferguson et al., 2012; Settembre et al., 201”
The Roles of Autophagy in Cancer (2018, background): “However, the role of mTORC1 in autophagy is not clear [28].”
Lysosomes as a therapeutic target (2019, background): “2) , processes regulated by mechanistic target of rapamycin complex 1 (mTORC1), a master controller of cell growth 35, 36 .”
TFEB at a glance (2016, background): “Accordingly, variants of TFEB carrying Ser-to-Ala mutations of either Ser142 or Ser211 are always nuclear and constitutively active (Martina et al., 2012; Roczniak-Ferguson et al., 2012; Settembre et al., 2011, 2012).”