Mitochondrial fission and remodelling contributes to muscle atrophy

By V. Romanello, E. Guadagnin, Lígia C. Gomes, I. Roder, C. Sandri, Yvonne Petersen, G. Milan, E. Masiero, P. del Piccolo, M. Foretz and 3 more. EMBO Journal, 2010

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The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Romanello et al recently suggested that fragmentation of the mitochondrial network triggers the activation of the proteasomeubiquitin system and the autophagy-lysosome axis, two key players in muscle atrophy (91).”
Cellular and molecular mechanisms of muscle atrophy (2013, unknown): “Other studies have shown that IGF1 and/or insulin signaling can suppress protein breakdown while promoting muscle growth Disease Models & Mechanisms 31 Mechanisms of muscle atrophy REVIEW D ise as e M od el s & M ec ha ni sm s D M M (Monier et al., 1983; Rommel et al., 2001; Sacheck et al., 2004).”
Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β (2011, unknown): “…al, 2008) including aging (Alavez et al, 2011), cancer (Guo et al, 2011), neurodegenera- tion (Renna et al, 2010; Wong and Cuervo, 2010), myopathies (Romanello et al, 2010), metabolic disorders (Gonzalez et al, 2011), infections, immunity, and inflammatory diseases (Deretic, 2011; Levine et al,…”