let-7 microRNAs in development, stem cells and cancer.

By I. Büssing, Frank J. Slack, H. Grosshans. Trends in Molecular Medicine, 2008

616 citations recorded by the source corpus.

Subfields: Aging, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b49ecb86e057ec45456eb86e06ba453e8ca4af06

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Citations in the corpus

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs (2013, background): “…pattern of H19 during embryogenesis, and given that the expression of both H19 and let-7 is developmentally regulated in a cell-and tissue-specific manner (Bussing et al., 2008; Gabory et al., 2010), we postulate that the H19/ let-7 regulation may also contribute to other developmental processes.”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “Some of the first miRNAs that were discovered, such as the let-7 family of miRNAs, are master regulators of developmental differentiation, both in early embryos and adult tissues (103, 104).”
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “let-7 miRNAs have been demonstrated to regulate multiple oncogenes, such as RAS, high-mobility group AT-hook 2 (HMGA2), c-Myc, and caspase-3 [177-180], and several genes involved in the maintenance of stem cell phenotype [181].”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “One of its constituents, let-7b, was proved to inhibit tumor growth, both in vitro and in vivo, while low levels of let-7f were detected in those ovarian cancer cells that had metastatic abilities and high invasion capabilities, further endorsing the supposition that it might play a suppressing role”
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “By suppressing let-7, Lin28 participates in stem cell maintenance and tumorigenesis (Bussing et al., 2008; Chang et al., 2009).”
Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells (2009, positive): “Moreover, it has been found that let-7 could regulate ‘‘stemness’’ by repressing self-renewal and promoting differentiation in both normal development and cancer and that let-7 miRNAs are markedly reduced in breast cancer–initiating cells and increased with differentiation (35, 36), suggesting that ”
Non‐coding RNAs: regulators of disease (2010, background): “The let-7 family of miRNAs is highly conserved throughout the Metazoa and functions as a master temporal regulator of development and differentiation, both in early embryos and complex adult tissues such as brain, in nematode, fruitfly, zebrafish and mouse [61–67].”