The postsynaptic architecture of excitatory synapses: a more quantitative view.

By M. Sheng, C. Hoogenraad. Annual Review of Biochemistry, 2007

1,016 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b48f0074feb91efe8361488d1c7d61ff684f8333

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Structural and molecular remodeling of dendritic spine substructures during long-term potentiation (2014, background): “Spines are further composed of specialized substructures, such as the postsynaptic density (PSD), a dense matrix of proteins located beneath the synaptic membrane, which serves as a scaffolding platform for glutamate receptors and signaling molecules (Sheng and Hoogenraad, 2007).”
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1 (2010, background): “, some of which reportedly interact with postsynaptic density 95 (PSD-95), a major structural protein of the postsynaptic density of the glutamate synaps”
Neuroligins and neurexins link synaptic function to cognitive disease (2008, background): “PSD95 and its homologues are centrally involved in recruiting glutamate receptors at postsynaptic site”
Actin in dendritic spines: connecting dynamics to function (2010, background): “Dendritic spines contain the postsynaptic machinery, in cluding glutamate receptors, postsynaptic density (PSD), and actin cytoskeleton, as well as a wide variety of membranebound or ganelles, such as smooth endoplasmic reticulum, mitochondria, and endosomes (Sheng and Hoogenraad, 2007; Fig.”
Super-resolution Imaging of Chemical Synapses in the Brain (2010, neutral): “The postsynaptic terminal consists of a dense protein scaffolding meshwork referred to as the postsynaptic density (PSD), which anchors neurotransmitter receptors as well as various signaling molecules that relay the neurotransmitter signals (Okabe, 2007; Sheng and Hoogenraad, 2007).”
Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses (2011, background): “In total, the PSD contains many hundreds of distinct proteins (Bayés et al., 2011; Sheng and Hoogenraad, 2007).”
Regional aerobic glycolysis in the human brain (2010, result): “With regard to the energy needs of the PSD, it should be noted that mitochondria are rarely seen in dendritic spines (41, 42) in contrast to axons (43), notwithstanding the fact that lac-”
How the Timing and Quality of Early Experiences Influence the Development of Brain Architecture (2010, neutral): “Over the past decade, investigators have identified literally thousands of genes that encode proteins related to synapse formation, plasticity, and stabilization (Akins & Biederer, 2006; Sheng & Hoogenraad, 2007; Sudhof, 2008).”