Neuroligins and neurexins link synaptic function to cognitive disease

By T. Sūdhof. Nature, 2008

1,787 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/3ab2744f33463ac4178570d13606f04463b5d8b3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Lipton
2. Mustafa Sahin
3. Mark F. Bear
4. H. Zoghbi
5. C. Hoogenraad
6. Pirta Hotulainen
7. T. Sūdhof
8. Mingfeng Li

In Cognitive Neuroscience

1. Mark F. Bear
2. J. Lipton
3. Mustafa Sahin
4. H. Zoghbi
5. T. Sūdhof
6. C. Hoogenraad
7. Pirta Hotulainen
8. Thomas Bourgeron

In Genetics

1. Mark F. Bear
2. Mustafa Sahin
3. J. Lipton
4. H. Zoghbi
5. Adrian R. Krainer
6. T. Sūdhof
7. C. Hoogenraad
8. Pirta Hotulainen

Citations in the corpus

• The human splicing code reveals new insights into the genetic determinants of disease (2014, background): “are extensively alternatively spliced (40), as well as by recent transcriptomic analyses showing consistent deviations in alternative splicing patterns in the cortical regions of ASD cases (41).”
• A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms (2011, background): “SynCAM2 in the formation of trans-synaptic structures [41].”
• Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013, background): “…Parkinson’s disease, is a SNARE complex assembly chaperone (Burré et al., 2010), the finding that the SM protein Munc18-1 is frequently mutated in Ohtahara syndrome (Saitsu et al., 2008), and the discovery that many ‘‘synaptic’’ genes are mutated in schizophrenia and autism (Südhof, 2008).”
• Modelling learning and memory in Drosophila to understand Intellectual Disabilities. (2020, neutral): “Recurrent mutations in neurexin genes have been identified in individuals with ASDs and neuropsychiatric disorders (Südhof, 2008; Kasem et al., 2018; Feng et al., 2006; Wang et al., 2018) and Table 1.”
• The Neurology of mTOR (2014, positive): “Moreover, these mice demonstrated increased translation of the neuroligins, proteins that have been previously linked to ASD risk (Südhof, 2008).”
• Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. (2012, background): “All Shank proteins are expressed in the brain, especially in cortical and hippocampal neurons; however, the expression of different paralogs varies in other brain regions and tissues (Lim et al. 1999).”
• Dendritic spine pathology in neuropsychiatric disorders (2011, background): “Rare variants in the genes for synaptic cell adhesion proteins neuroligin 3 and 4 ( NLGN3 , NLGN4 ) and their presynaptic ligand neurexin1 ( NRXN1 ) have been genetically linked with autis”
• Actin in dendritic spines: connecting dynamics to function (2010, background): “For instance, mutations in synaptic scaffold ing protein Shank3 and adhesion molecules neuroligin3 and neuroligin4 have been linked to autism spectrum disorder (Südhof, 2008).”