Structural and molecular remodeling of dendritic spine substructures during long-term potentiation
By M. Bosch, Jorge Castro, T. Saneyoshi, Hitomi Matsuno, Mriganka Sur, Y. Hayashi. 2014
576 citations recorded by the source corpus.
SUMMARY Synapses store information by long-lasting modifications of their structure and molecular composition, but the precise chronology of these changes has not been studied at single synapse resolution in real time. Here we describe the spatiotemporal reorganization of postsynaptic substructures during long-term potentiation (LTP) at individual dendritic spines. Proteins translocated to the spine in four distinct patterns through three sequential phases. In the initial phase, the actin cytoskeleton was rapidly remodeled while active cofilin was massively transported to the spine. In the stabilization phase, cofilin formed a stable complex with F-actin, was persistently retained at the spine, and consolidated spine expansion. In contrast, the postsynaptic density (PSD) was independently remodeled, as PSD scaffolding proteins did not change their amount and localization until a late protein synthesis-dependent third phase. Our findings show how and when spine substructures are remodeled during LTP and explain why synaptic plasticity rules change over time.
Subfields: Cellular and Molecular Neuroscience, Materials Chemistry
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In Cellular and Molecular Neuroscience
- Wulfram Gerstner
- Walter Senn
- Johanni Brea
- Michael H. Herzog
- Pascal Leimer
- Dane S. Corneil
- Vasiliki Liakoni
- Marco P Lehmann
Citations in the corpus
- Synaptic weight decay with selective consolidation enables fast learning without catastrophic forgetting (2019, background): “…the fast decay of the so-called early long-term potentiation/depression (early LTP/LTD) was shown to be prevented by a synaptic tagging & capture mechanism (Frey and Morris, 1997; Sajiku-mar and Frey, 2004; Morris, 2006; Redondo and Morris, 2011; Shires et al., 2012; Bosch et al., 2014).”
- Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of NeoHebbian Three-Factor Learning Rules (2018, background): “…variable eij represents a metastable transient state of interacting molecules in the spine head or a multi-molecular substructure in the postsynaptic density which serves as a synaptic flag indicating that the synapse is ready for an increase or decrease of its spine volume (Bosch et al., 2014).”