Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier

By J. Kreuter, D. Shamenkov, V. Petrov, P. Ramge, Klaus Cychutek, C. Koch-Brandt, R. Alyautdin. Journal of drug targeting (Print), 2002

788 citations recorded by the source corpus.

Subfields: Pediatrics, Perinatology and Child Health, Pharmaceutical Science, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/b47c9014b10535a20742d88df16da30c80f4d1a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pediatrics, Perinatology and Child Health

1. R. Gabathuler

In Pharmaceutical Science

1. Vicki Stone
2. Ken Donaldson
3. M. Geiser
4. G. Oberdörster
5. W. Kreyling

Citations in the corpus

• Translocation of Inhaled Ultrafine Particles to the Brain (2004, background): “Only after coating intravenously injected nanoparticles with polysorbate or apolipoprotein did they seem to mimic lipoprotein particles that could be taken up by brain capillary endothelial cells via receptor-mediated phagocytosis (Kreuter et al., 2002).”
• Deposition and biokinetics of inhaled nanoparticles (2010, background): “Apolipoprotein-E coating of nanoparticles for LDL receptor mediated endocytosis in brain capillaries has been discussed [74-76].”
• Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. (2006, background): “Thus, following inhalation exposure, NP have been reported to travel via the nasal nerves to the brain (Kreuter et al., 2002; Oberdorster et al., 2004), as has been described for poliovirus (Bodian and Howe, 1941), and to gain access to the blood and other organs (Kreyling et al.”
• Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle (2013, background): “Receptor mediated endocytosis was speculated to be the means of uptake in this case [55,56].”
• Treating metastatic cancer with nanotechnology (2011, neutral): “These ApoE-decorated particles can mediate BBB deliver”
• Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. (2010, background): “A possible mechanism is that polysorbate 80 (tween-80) coated polybutyl-cyanoacrylate nanoparticles adsorb apolipoprotein E and B from the bloodstream after IV injection (Kreuter et al., 2002) and therefore use LRP for transcytosis across the BBB.”