Deposition and biokinetics of inhaled nanoparticles

By M. Geiser, W. Kreyling. Particle and Fibre Toxicology, 2010

714 citations recorded by the source corpus.

Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help to set limits in that way. Here we focus on the biokinetics of inhaled nanometer sized particles in comparison to micrometer sized ones.The presented approach ranges from inhaled particle deposition probability and retention in the respiratory tract to biokinetics and clearance of particles out of the respiratory tract. Particle transport into the blood circulation (translocation), towards secondary target organs and tissues (accumulation), and out of the body (clearance) is considered. The macroscopically assessed amount of particles in the respiratory tract and secondary target organs provides dose estimates for toxicological studies on the level of the whole organism. Complementary, microscopic analyses at the individual particle level provide detailed information about which cells and subcellular components are the target of inhaled particles. These studies contribute to shed light on mechanisms and modes of action eventually leading to adverse health effects by inhaled nanoparticles.We review current methods for macroscopic and microscopic analyses of particle deposition, retention and clearance. Existing macroscopic knowledge on particle biokinetics and microscopic views on particle organ interactions are discussed comparing nanometer and micrometer sized particles. We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures.

Subfields: Environmental Engineering, Health, Toxicology and Mutagenesis, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/3d654ba7415e78b2e5c85ccbf2a7447423769a81

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In Environmental Engineering

1. G. Luther
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Citations in the corpus

• Brake wear particle emissions: a review (2014, background): “Other studies have shown that ultrafine particles may become blood-borne and translocate to other tissues such as the liver, kidneys and brain (Geiser and Kreyling 1999; Oberdörster et al. 2005), while experiments to animals have shown translocation of inhaled ultrafine particles to the brain (Tjalv”
• Natural, incidental, and engineered nanomaterials and their impacts on the Earth system (2019, background): “These incidental nanomaterials readily penetrate the alveolar membranes of the lungs and translocate into the bloodstream, often concentrating distally in vital organs (77).”
• Nanoparticles and microparticles for skin drug delivery. (2011, background): “Bioretention has been an area of focus for inhaled nanoparticles by Kreyling [252,253] for some time and”
• Titanium dioxide nanoparticles: a review of current toxicological data (2013, background): “Geiser and Kreyling [91] in their review reported that NPs including TiO2 NPs in the size range of 5–100 nm could be translocated across the air-blood-barrier.”