Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
By S. Saptarshi, A. Duschl, A. Lopata. Journal of Nanobiotechnology, 2013
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Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake.
Subfields: Biomaterials, Materials Chemistry, Surfaces, Coatings and Films
View Paper: https://www.semanticscholar.org/paper/09ea51ab23beaaff0ca4a5e77c965aa6f64683ef
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In Materials Chemistry
Citations in the corpus
- Engineered nanoparticles interacting with cells: size matters (2014, background): “A quantitative understanding of the NPbiomolecule/membrane interaction is, therefore, an important prerequisite for designing and engineering NPs with intentionally enhanced or suppressed cellular uptake [17,18].”
- Molecular Toxicity Mechanism of Nanosilver (2014, background): “As proposed by Saptarshi et al [118], nanosilver can cause the formation of protein corona, protein unfolding, and altered protein function (Fig.”