Translocation of Inhaled Ultrafine Particles to the Brain

By G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, W. Kreyling, Christopher Cox. Inhalation Toxicology, 2004

2,554 citations recorded by the source corpus.

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Citations in the corpus

Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells (2005, background): “After exposure of the respiratory system to UFPs, the UFPs may appear within hours in many compartments of the body, including the liver, heart, and nervous system (Brown et al. 2002; Kreyling et al. 2002; Oberdörster et al. 2004).”
Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. (2006, background): “Thus, following inhalation exposure, NP have been reported to travel via the nasal nerves to the brain (Kreuter et al., 2002; Oberdorster et al., 2004), as has been described for poliovirus (Bodian and Howe, 1941), and to gain access to the blood and other organs (Kreyling et al.”
Characterisation of nanoparticle size and state prior to nanotoxicological studies (2010, background): “Other important size cut-offs are that particles less than 40 nm can enter the nucleus, while particles less than 35 nm can potentially cross the protective epithelial barriers, such as the blood‐ brain barrier ( Oberdorster et al. 2004 ).”
Particulate Emissions from a Low-Speed Marine Diesel Engine (2007, background): “Recent research shows that they can penetrate the cell membranes, enter into the blood and even reach the brain (Oberdörster et al. 2004).”
In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. (2005, background): “…distribution of nanoparticles has been demonstrated after inhalation and oral uptake (Jani et al., 1990; Oberdorster et al., 2002), and nanoparticles have been found to cross the blood–brain barrier, reaching the olfactory bulb and the cerebellum (Borm and Kreyling, 2004; Oberdorster et al., 2004).”
Nanotechnology and Water Treatment: Applications and Emerging Opportunities (2008, background): “In addition, there is only limited information available regarding the uptake, translocation and distribution of nanoparticles in the body (Kreyling et al. 2002; Oberdörster et al. 2004; Elder et al. 2006; Singh et al. 2006).”
Assessing exposure to airborne nanomaterials: Current abilities and future requirements (2007, background): “Recent studies on particle translocation within the body have further indicated a size-dependency on the likelihood of deposited particles moving from the respiratory system to other organs (Kreyling et al. 2002; Oberdörster et al. 2004; Elder et al. 2006).”
Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle (2013, background): “NPs less than 100 nm in diameter can enter cells, less than 40 nm can enter the cell nucleus and below35 nm can cross the blood–brain barrier [44,45].”
Categorization framework to aid hazard identification of nanomaterials (2007, methodology): “…number concentration, agglomeration state, shape, crystal structure, chemical composition, surface area, surface chemistry, surface charge, porosity, and method of synthesis are proposed in the literature as properties that need to be considered (Oberdörster et al. 2004, 2005b; Lam et al. 2006).”