Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.

By Roy A. Frye. Biochemical and Biophysical Research Communications - BBRC, 2000

1,444 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b462838418fc440ea8f9a77a3ab04cc3653820e0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. L. Guarente
2. D. Sinclair
3. M. Haigis
4. E. Verdin
5. R. Mostoslavsky
6. Joseph A. Baur
7. S. Imai
8. Brian J. North

In Immunology

1. L. Guarente
2. E. Verdin
3. M. Haigis
4. D. Sinclair
5. Brian J. North
6. PA Marks
7. M. Hirschey
8. H. Tissenbaum

In Molecular Biology

1. L. Guarente
2. E. Verdin
3. D. Sinclair
4. PA Marks
5. M. Haigis
6. R. Mostoslavsky
7. Brian J. North
8. Stefanie Dimmeler

Citations in the corpus

• Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. (2007, background): “These unusual enzymes, which bear virtually no sequence homology to class I and II HDACs (Denu, 2005; Frye, 2000), have emerged as key regulators of cell survival and organismal longevity (Guarente and Picard, 2005).”
• Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (2005, background): “SIRT1 is a nuclear protein with the highest sequence similarity to Sir2 and a yeast Sir2-related protein Hst1 (Frye, 2000).”
• Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling (2010, background): “Mammals contain seven sirtuins (SIRT1–7) that are characterized by an evolutionary conserved sirtuin core domain [18,19].”
• Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation (2009, background): “The mammalian genome consists of seven sirtuins, collectively known as SIRT1–SIRT7 (Frye, 2000).”
• The Histone Deacetylase SIRT6 Regulates Glucose Homeostasis via Hif1α (2010, neutral): “In mammalian genomes, there are seven Sir2 homologs (SIRTs 1–7) (Frye, 2000).”
• Sirtuins as regulators of metabolism and healthspan (2012, neutral): “The sirtuin family Sequence-based phylogenetic analysis revealed that mammalian sirtuins can be divided into four classes: SIRT1–SIRT3 belong to class I, SIRT4 to class II, SIRT5 to class III, and SIRT6 and SIRT7 to class I”
• Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. (2010, background): “Sir2p has nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity (Frye, 2000; Imai et al., 2000).”
• SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009, neutral): “Proteins with homology to yeast SIR2 are found in organisms ranging from bacteria to humans and have been termed sirtuins (Frye, 2000; Guarente, 2008).”
• Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5 (2014, background): “SIRT5was originally annotated as a deacetylase (Frye, 2000) and was predicted to have deacetylase activity, but appears to preferentially deacylate negatively charged modifications, including malonylation, succinylation, and glutarylation.”
• Histone deacetylases and cancer: causes and therapies (2001, background): “Three classes of HDAC have been identified that might be involved in modelling the structure of chromati”