Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair.

By C. Wetzler, H. Kämpfer, B. Stallmeyer, J. Pfeilschifter, S. Frank. Journal of Investigative Dermatology, 2000

600 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/b3b0eac67eae243d12db57620e40356ad25e4a39

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Citations in the corpus

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing (2008, background): “Sustained expression of this chemokine permits a prolonged presence of neutrophils and macrophages in the chronic wound contributing to a prolonged inflammatory response.(255) However, lack of MCP-1 in vivo significantly delays wound healing particularly with reepithelialization, angiogenesis, and c”
Chemokines in cutaneous wound healing (2001, background): “In murine skin-wound healing models, however, MIP-1a and RANTES have, in addition to MCP-1, been shown to play a critical role in macrophage recruitment [34–38].”
Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. (2004, background): “Cutaneous wounds in diabetics have been shown to have altered blood flow, impaired neutrophil anti-microbial activity, and a dysfunctional inflammatory state associated with abnormal chemokine expression.(4) A”
Inflammation in wound repair: molecular and cellular mechanisms. (2007, background): “…into the wound site is highly regulated by gradients of different chemotactic factors, including growth factors, proinflammatory cytokines, and chemokines macrophage inflammatory protein 1a, MCP-1, RANTES) (DiPietro et al., 1998; Frank et al., 2000; Wetzler et al., 2000; Werner and Grose 2003).”
Regulation of wound healing by growth factors and cytokines. (2003, background): “Treatment of wounds from these animals with neutralizing antibodies to MCP-1/CCL2 and MIP-2 caused a reduction in the number of neutrophils and macrophages at the wound site, suggesting a direct involvement of these chemokines in the late infiltration of inflammatory cells into db/db wounds (293).”
The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes (2018, background): “One study compared the expression of IL-1β and TNF-α in three different mouse strains: Balb/c, C57BLKS, and db/db (Wetzler et al., 2000).”
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice (2010, background): “These lines of evidence suggest that the perturbation of a delicate balance between pro-inflammatory and anti-inflammatory cytokines in the diabetic wound predisposes the wound to impaired resolution of inflammation [3,48].”