Chemokines in cutaneous wound healing

By R. Gillitzer, M. Goebeler. Journal of Leukocyte Biology, 2001

990 citations recorded by the source corpus.

Healing of wounds is one of the most complex biological events afterbirth as a result of the interplay of different tissue structures and alarge number of resident and infiltrating cell types. The latter aremainly constituted by leukocyte subsets (neutrophils, macrophages, mastcells, and lymphocytes), which sequentially infiltrate the wound siteand serve as immunological effector cells but also as sources ofinflammatory and growth‐promoting cytokines. Recent data demonstratethat recruitment of leukocyte subtypes is tightly regulated bychemokines. Moreover, the presence of chemokine receptors on residentcells (e.g., keratinocytes, endothelial cells) indicates thatchemokines also contribute to the regulation of epithelialization,tissue remodeling, and angiogenesis. Thus, chemokines are in anexclusive position to integrate inflammatory events and reparativeprocesses and are important modulators of human‐skin wound healing.This review will focus preferentially on the role of chemokines duringskin wound healing and intends to provide an update on the multiplefunctions of individual chemokines during the phases of woundrepair.

Subfields: Biomaterials, Microbiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/1458984401d0217176df826a58a9ef5fd9b8e2fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. S. Werner
2. Erik Sahai
3. S. Eming
4. B. Hinz
5. R. Medzhitov

In Microbiology

1. S. Eming

In Rehabilitation

1. S. Eming
2. S. Werner
3. Chandan K. Sen
4. Paul Martin
5. B. Hinz
6. R. Medzhitov

Citations in the corpus

• Inflammation in wound repair: molecular and cellular mechanisms. (2007, background): “Chemokines and their receptors are most likely crucial mediators for neutrophil recruitment during repair (Gillitzer and Goebeler 2001; Esche et al., 2005).”
• Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice (2010, background): “Wound inflammation is driven by a variety of mediators that are tightly controlled in space and time [4,5].”
• Wound healing: an overview of acute, fibrotic and delayed healing. (2004, background): “The many diverse activities taking place during wound healing are directed by chemical signals referred to as growth factors or cytokines (1, 5, 6).”
• Wound Healing: A Cellular Perspective. (2019, background): “On the day following injury, neutrophils constitute 50% of all cells in the wound (142).”
• Regulation of wound healing by growth factors and cytokines. (2003, background): “Expression of a wide variety of different chemokines has been detected at the wound site, and these results have been reviewed in detail (103).”
• Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “In wound repair, T lymphocytes function as growth factorproducing cells as well as immunological effector cells [20].”
• Physical influences of the extracellular environment on cell migration (2014, background): “(2) indicates the cross-section of the profile labelled (2) in part a.”