A disinhibitory microcircuit for associative fear learning in the auditory cortex

By J. Letzkus, Steffen B. E. Wolff, E. Meyer, Philip Tovote, J. Courtin, Cyril Herry, Andreas Lüthi. Nature, 2011

844 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/857c1ee2ee1c51a29e4d6313c5ddd373655042cb

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Citations in the corpus

Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function (2014, background): “Furthermore, PV interneurons in the auditory cortex are inhibited by aversive foot shocks in an auditory fear-conditioning paradigm, and this inhibition plays a critical role for associative fear learning (104, 105) (Fig.”
Critical periods in speech perception: new directions. (2015, background): “…neuromodulators (such as the serotonin and nicotinic acetylcholine receptor signaling onto particular GABA neurons) acutely regulates E-I balance (Lee et al. 2010), effectively disinhibiting the local circuitry to enable adult learning (Brown et al. 2012, Donato et al. 2013, Letzkus et al. 2011).”
Structured Connectivity in Cerebellar Inhibitory Networks (2014, background): “Recently, the interaction between the different types of cortical interneurons and its functional implications have attracted interest (Jiang et al., 2013; Letzkus et al., 2011; Pi et al., 2013).”
Parallel processing by cortical inhibition enables context-dependent behavior (2016, neutral): “6%, n = 7 cells, Student’s paired two-tailed t-test, t(6) = 3.”
AMYGDALA MICROCIRCUITS CONTROLLING LEARNED FEAR (2014, background): “In fact, auditory fear conditioning leads to widespread synaptic plasticity in the brain, not only the amygdala but also in the auditory thalamus and cortex (Weinberger, 2011; Letzkus et al., 2011).”
Rapid homeostasis by disinhibition during whisker map plasticity (2014, background): “, before the onset of classical Hebbian response plasticity) is proposed as an early step in lesion-induced adult plasticity in S1 (45) and tone-shock conditioning in auditory cortex (46), and it was recently observed in visual cortex after visual deprivation (10, 16).”
A cortical circuit for gain control by behavioral state (2014, background): “No fast nAChR component like that shown in layer I inhibitory neurons (Letzkus et al., 2011) was evident; our findings showed instead a response with slow kinetics resembling what has been found in ChATpositive bipolar neurons (Arroyo et al., 2012).”