Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

By V. Ouellet, Sébastien M. Labbé, D. Blondin, S. Phoenix, B. Guérin, F. Haman, É. Turcotte, D. Richard, A. Carpentier. Journal of Clinical Investigation, 2012

939 citations recorded by the source corpus.

Subfields: Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/9a80a725e7edc94751b9dbc88b383eca6fef3673

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. B. Spiegelman
2. L. Sidossis
3. P. Seale
4. Jun Wu
5. Alexander Sakers
6. Mirian Krystel De Siqueira
7. Claudio J. Villanueva
8. S. Kajimura

In Rehabilitation

1. L. Sidossis
2. P. Seale
3. B. Spiegelman
4. S. Kajimura

Citations in the corpus

• Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans (2014, methodology): “Furthermore, Ouellet et al. (12) demonstrated that BAT minimally contributed to whole-body plasma glucose utilization, which might be due to the shorter duration of CE and the presence of mild shivering.”
• What We Talk About When We Talk About Fat (2014, neutral): “The potential benefits of BAT activation extend beyond weight loss, as BAT consumes significant amounts of lipid and, to a lesser but still significant extent, glucose (Bartelt et al., 2011; Ouellet et al., 2012).”
• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “Cold exposure significantly increases glucose disposal in BAT (110, 113) but not in other tissues.”
• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. (2013, neutral): “It has also been well established that BAT activity is inversely related to BMI and body fat percentage, indicating its potential to counterbalance the current obesity pandemic (1, 4, 6).”
• Recruited brown adipose tissue as an antiobesity agent in humans. (2013, neutral): “Cold exposure is the most powerful and physiological stimulus for BAT activation, both in small rodents and in humans (2, 8–11).”
• Adipose tissue plasticity in health and disease (2022, background): “When fully active, thermogenic adipose tissue can increase whole-body energy expenditure by over 100% in mice and by 40%–80% in humans (Angueira et al., 2020; Ouellet et al., 2012).”
• Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human (2012, background): “This tissue disappears as humans mature, and it is only recently that brown fat was fully recognized in adult humans (Cypess et al., 2009; Orava et al., 2011; Ouellet et al., 2012; van Marken Lichtenbelt et al., 2009; Virtanen et al., 2009).”
• Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist (2015, background): “Mirabegron increased BAT glucose uptake, which correlates directly with tissue thermogenesis (Ouellet et al., 2012), and the degree of activation accounted for 50% of the variability in drug-induced changes in RMR.”