mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

By D. Kang, R. Gopalkrishnan, Qingping Wu, Eckhard Jankowsky, Anna Marie Pyle, P. Fisher. Proceedings of the National Academy of Sciences of the United States of America, 2002

711 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b333cc7aeb07b8f4a522d3a5b5083a14c23af728

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Anna Marie Pyle
3. S. Ghosh
4. M. Hayden
5. A. West
6. O. Takeuchi
7. S. Ding
8. Katherine A. Fitzgerald

In Molecular Biology

1. Anna Marie Pyle
2. Shizuo Akira
3. S. Ding
4. M. Hayden
5. S. Ghosh
6. Adriana Vela
7. Katherine A. Fitzgerald
8. A. West

In Oncology

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. Anna Marie Pyle
5. O. Takeuchi
6. Taro Kawai
7. Shao-Cong Sun
8. M. Karin

Citations in the corpus

• Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action (2006, background): “PKR Activation by dsRNA Immunorecognition of dsRNA include Toll-like receptor 3 (TLR3) and cytosolic RNA-binding proteins such as PKR and the helicases RIGI and MDA5 (3, 181, 393) (Fig.”
• Pathogen recognition and innate immunity. (2006, neutral): “Melanoma differentiation associated gene 5 (MDA5), a molecule showing homology to RIG-I, has also been implicated in the recognition of viral dsRNA (Andrejeva et al., 2004; Kang et al., 2002).”
• The Thermodynamic Basis for Viral RNA Detection by the RIG-I Innate Immune Sensor (2012, background): “The RLR proteins are localized in the cytoplasm, and they include several family members, such as RIG-I, MDA-5 (melanoma differentiation-associated gene 5) (1, 2), and LGP2 (laboratory of genetics and physiology 2) (3–5).”
• NF-κB and the immune response (2006, background): “The RNA helicase domains of RIG-I and MDA5 bind directly to double-stranded RNA (dsRNA) and induce production of type I interferons (Kang et al., 2002; Andrejeva et al., 2004; Yoneyama et al., 2004).”
• Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form (2008, background): “Sensors for dsRNA include TLR3, retinoic acid inducible gene I (RIG-I), melanoma differentiation-associated gene 5 (MDA-5) and dsRNA dependent protein kinase (PKR) (53-56) and their activation triggers antiviral responses.”
• RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “Melanoma differentiation-associated gene 5 (MDA5) was originally isolated as a gene induced by the IFN- and protein kinase C-activating compound mezerein in a melanoma cell line (43).”