Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
By C. Diaz-Montero, M. L. Salem, M. Nishimura, E. Garrett-Mayer, D. Cole, A. Montero. Cancer Immunology and Immunotherapy, 2008
1,283 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/b3056e01d0a7f8f37d1fbd49553c6106160c8bf4
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In Immunology
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Citations in the corpus
- Myeloid derived suppressor cells (2013, background): “Accumulation of MDSCs occurs in most mouse models of cancer, including transplant and spontaneous tumors,(3) and their presence in peripheral blood of cancer patients is well established(4) and correlates with stage of disease in cancer patients.(5) Traditionally, the literature has organized the fr”
- The secret ally: immunostimulation by anticancer drugs (2012, background): “This suggests that cyclophosphamide may counteract immunosuppressive leukocytes more efficiently within the tumour than in the periphery but does not explain why circulating MDSC levels were significantly increased and correlated with clinical stage and metastatic tumour burden in 17 patients with e”
- Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “The increased numbers of immature myeloid cells, including MDSCs, in peripheral blood and tumour samples from cancer patients have been well documente”
- Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer (2013, background): “Increased circulatingMDSC frequencies were observed in breast cancer patients and in B16 melanoma-bearing mice injected with CTX plus doxorubicin.(83,84) Recently, low-dose CTX treatment of mice spontaneously developing melanomas led to an”
- CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma (2016, positive): “, 2012), and the accumulation of MDSCs in patients with advanced pancreatic cancer correlates with disease stage (Diaz-Montero et al., 2009).”
- Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Indeed, MDSCs produce MMPs that can support tumor cell invasion by directly promoting tumor angiogenesis and lymphangiogenesis (95, 237, 297, 354).”
- The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “However, further attempts to define them on the basis of cell surface markers have suggested that they express CD11b and CD33 but little or no CD14 or Li”
- Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice (2008, background): “Among stage IV patients, those with extensive metastatic tumor burden had the highest percentage and absolute number of MDSC (16).”