The secret ally: immunostimulation by anticancer drugs

By L. Galluzzi, L. Senovilla, L. Zitvogel, Guido Kroemer. Nature reviews. Drug discovery, 2012

664 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/665586bca7d45de32bb8f04673a85f3c1b33d8d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Guido Kroemer
2. L. Zitvogel
3. L. Galluzzi
4. M. Smyth
5. Oliver Kepp
6. S. Formenti
7. S. Demaria
8. A. Buqué

In Oncology

1. Guido Kroemer
2. L. Galluzzi
3. L. Zitvogel
4. S. Formenti
5. S. Demaria
6. Oliver Kepp
7. M. Smyth
8. T. Hagemann

Citations in the corpus

• Immune evasion in cancer: Mechanistic basis and therapeutic strategies. (2015, neutral): “[98] Galluzzi L, Senovilla L, Zitvogel L, Kroemer G.”
• The tumor microenvironment at a glance (2012, background): “In mouse cancers and clinical trials, there is evidence that chemotherapy is most successful when it causes a form of cell death that stimulates an anti-tumor immune response (Galluzzi et al., 2012).”
• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “Through immunogenic cell death, after some types of anticancer therapy (Galluzzi et al., 2012; Bezu et al., 2015; Garg et al., 2017a), a damaged cancer cell produces specific inflammatory chemokines to recruit neutrophils as first innate immune cells (Kolaczkowska and Kubes, 2013; Garg et al.”
• Consensus guidelines for the detection of immunogenic cell death (2014, background): “Indeed, even the activity of antineoplastic regimens that fail to render dying cells immunogenic but induce other immunostimulatory effects is negatively affected by the absence of a functional immune system.(104,105) Among other molecules, this applies to the microtubular inhibitor paclitaxel and t”
• Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “A comprehensive compendium of chemotherapeutic agents that mediate immunostimulatory effects can be found in Galluzzi et al. (2012c) and Vanneman and Dranoff, (2012).”
• Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. (2015, background): “…contrary, specific immunosuppressive circuits were inactivated demonstrate that many chemotherapeutic agents that were initially developed according to a purely cancer cell-autonomous logics mediate antineoplastic effects via immunological mechanisms (Galluzzi et al., 2012; Zitvogel et al., 2013).”
• Immunogenic cell death and DAMPs in cancer therapy (2012, background): “These authors showed that a recombinant N-terminal fragment of CRT (39-272) is a potent inducer of activation and maturation of B cells and macrophages and can trigger Ig class switching in B cells without T cell help in vitro and in vivo72.”