Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

By M. Koivusalo, Christopher M. Welch, H. Hayashi, Cameron C Scott, Moshe S. Kim, Todd Alexander, N. Touret, K. Hahn, S. Grinstein. Journal of Cell Biology, 2010

861 citations recorded by the source corpus.

Inhibitors of Na+/H+ exchange proteins block macropinocytosis by lowering the pH near the plasma membrane, which in turn inhibits actin remodeling by Rho family GTPases.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f70b09fc9d8858d896b6d8814fff014d2ba6d901

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Citations in the corpus

• Dysregulated pH: a perfect storm for cancer progression (2011, background): “The polarity of migrating cells depends on the activity of the low-molecular-weight GTPase CDC42, which requires an increased pH i”
• Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release (2014, background): “The selection of inhibitors was justified from their ability to selectively inhibit different pathways: amantadine blocks the clathrin-dependent endocytosis [52], nystatin disrupts caveolar structure [53], amiloride interferes with macropinocytosis [54], wortmannin reduces fluid-phase endocytosis [5”