A Role for Skin γδ T Cells in Wound Repair

By J. Jameson, Karen Ugarte, N. Chen, P. Yachi, Elaine Fuchs, R. Boismenu, W. Havran. Science, 2002

604 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/b228be56b5ec2d5a0eb362ed23b2638ffe84fb40

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In Immunology

1. D. Cua
2. C. Tato
3. T. Mcclanahan
4. W. Blumenschein
5. Yi Chen
6. M. Tomic‐Canic
7. R. O’Brien
8. Paul Martin

Citations in the corpus

• Inflammation in wound repair: molecular and cellular mechanisms. (2007, background): “…a delayed healing response following mechanical injury. gd DETCs have been identified as important source of key growth factors such as fibroblast growth factor-7, -10, as well as IGF-1 thereby regulating keratinocyte proliferation and differentiation (Jameson et al., 2002; Sharp et al., 2005).”
• Regulation of wound healing by growth factors and cytokines. (2003, background): “Furthermore, mice lacking DETCs have a significant delay in wound reepithelialization, most likely due to the lack of DETC-derived FGF7 and FGF10 in the healing wound (134).”
• Cellular and molecular mechanisms of skin wound healing (2024, neutral): “These sentinel cells undergo a morphological switch within hours of wounding, from their sensory dendritic shape to an activated, rounded-up phenotype 179 .”
• IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability (2015, positive): “Our results involving the gut mucosa concur with previously published work with lung and skin models in which subsets of gd T cells are important for barrier protection (D’Souza et al., 1997; Jameson et al., 2002; Nakasone et al., 2007).”
• Wound repair and regeneration: Mechanisms, signaling, and translation (2014, positive): “Currently, very little is known about the role of adaptive immunity in the normal mammalian wound-healing process, but one study of murine γδ T cells suggests that these may be vital for recognizing keratinocyte “damage” signals and releasing key growth factors for epidermal migration (106).”
• CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin (2017, positive): “Such cells might also contribute to local surveillance and defense against malignancy (Jameson et al., 2002).”
• γδ T‐cell receptors: functional correlations (2007, background): “(70), which plays a role in promoting wound healing (71).”