Microglia development follows a stepwise program to regulate brain homeostasis

By Orit Matcovitch-Natan, D. Winter, A. Giladi, Stephanie Vargas Aguilar, A. Spinrad, S. Sarrazin, H. Ben-Yehuda, Eyal David, Fabiola Zelada González, Pierre Perrin and 14 more. Science, 2016

1,093 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/0f4580f22c0ccaa20c720c5d65f249c5870ca66a

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Citations in the corpus

Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes (2018, background): “These signatures—cell cycle, phagocytosis, and surveillance—correspond with only three of the nine states presented here (Matcovitch-Natan et al., 2016).”
The Central Nervous System and the Gut Microbiome (2016, background): “These microglia display morphological characteristics and a gene expression profile that indicate an arrest in their developmental maturation and subsequently are maintained in an immature status (Erny et al., 2015; Matcovitch-Natan et al., 2016).”
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, positive): “…resolve immune heterogeneity in AD (Deng et al., 2014; Grün et al., 2015; Gury-BenAri et al., 2016; Jaitin et al., 2014; Junker and van Oudenaarden, 2014; La Manno et al., 2016; Mass et al., 2016; Matcovitch-Natan et al., 2016; Paul et al., 2015; Treutlein et al., 2014; Zeisel et al., 2015).”
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes (2017, methodology): “To minimize the reported effect of brain region on microglial gene expression 6,23,24 , only cortical microglia were included in our comparisons.”
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases (2017, background): “1 to establish microgliaspecific enhancer profiles, including TGFb signaling (Butovsky et al., 2014; Gosselin et al., 2014; Matcovitch-Natan et al., 2016).”
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “Similarly, antibiotic treatment in normal mice is associated with increased naïve microglia, without obvious difference in total microglia number [80, 81].”
Interaction between microbiota and immunity in health and disease (2020, background): “GF mice display marked defects in microglia structure and function and hence feature impaired CNS innate immune responses.(240,241) Interestingly, the maternal microbiome impacts on microglial development during prenatal stages, and microglial perturbations associated with the absence of microbiota ”
Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017, background): “Recent analysis of microglia enhancers has provided further insight into the molecular mechanisms underpinning distinctive microglia gene expression programs (38, 44).”