Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis.

By Joshua L Hood, R. A. San, Samuel A. Wickline. Cancer Research, 2011

953 citations recorded by the source corpus.

Exosomes are naturally occurring biological nanovesicles utilized by tumors to communicate signals to local and remote cells and tissues. Melanoma exosomes can incite a proangiogenic signaling program capable of remodeling tissue matrices. In this study, we show exosome-mediated conditioning of lymph nodes and define microanatomic responses that license metastasis of melanoma cells. Homing of melanoma exosomes to sentinel lymph nodes imposes synchronized molecular signals that effect melanoma cell recruitment, extracellular matrix deposition, and vascular proliferation in the lymph nodes. Our findings highlight the pathophysiologic role and mechanisms of an exosome-mediated process of microanatomic niche preparation that facilitates lymphatic metastasis by cancer cells.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/61aea097811a84da15e24d14792fb07a8f3a9279

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Citations in the corpus

Tumor-derived exosomes and their role in cancer progression (2016, background): “Melanoma-derived exosomes were shown to accumulate in sentinel lymph nodes, stimulate angiogenesis, re-model extracellular matrix and induce melanoma cells recruitment to the lymph nodes [106].”
In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior (2015, background): “…isolated from tumor cell culture media can be bioactive because injection of concentrated tumor-cell-line-derived EVs educates tumorsupporting cells, such as bone-marrow-derived cells, that subsequently prepare sentinel lymph nodes and lungs formetastasis (Hood et al., 2011; Peinado et al., 2012).”
Hypoxic enhancement of exosome release by breast cancer cells (2012, background): “There is an increasing body of evidence that tumour cell-derived exosomes play important roles in angiogenesis [5], cancer cell invasion [45], metastasis [10] and immunosuppression [8,9] to promote tumour progression.”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “Similarly, exosome-mediated release of melanoma cells was shown to prime sentinel lymph node metastasis [155].”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “…exosomes, for instance, induce pulmonary vascular leakiness (Peinado et al., 2012) and upregulate genes related to tumor cell recruitment, such as Stabilin 1, Vitronectin, Integrins, and Ephrin receptor β4, in lymph nodes (Hood et al., 2011), creating pre-metastatic niches supportive of metastasis.”
Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Exosomal miRNA and tumor metastasis The metastatic process involves manipulation of the cellular microenvironment to optimize conditions for deposition and growth both locally and at a distance [54].”
Exosomes in cancer development, metastasis, and immunity (2019, background): “These exosomes prepared lymph nodes for melanoma metastasis via the activation of molecular signals that modulated ECM deposition and vascular proliferation [96].”
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation (2012, neutral): “Recent studies have highlighted the role of EVs in intercellular communication [20–22], vaccine and drug delivery [23– 25], and suggested a potential role in gene vector therapy [26] and as disease biomarkers [27].”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “angiogenesis and extracellular matrix remodeling [28].”
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory (2019, background): “, 2015), home tumor cells to lymph nodes (Hood et al., 2011), induce neovascularization and leakiness of tumor vessels (Peinado et al.”