Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability

By Robert G. Bristow, R. Hill. Nature Reviews. Cancer, 2008

1,095 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/498e10bd233dd88e931b1e435b85f879f88f87a6

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In Cancer Research

1. Stephen P. Jackson
2. J. Bartek
3. H. Moses
4. Yongqian Shu
5. I. Harris
6. Ke Wei
7. Xinming Jing
8. C. Shao

In Molecular Biology

1. Stephen P. Jackson
2. J. Bartek
3. Yongqian Shu
4. I. Harris
5. Ke Wei
6. Xinming Jing
7. C. Shao
8. Rakesh K. Jain

Citations in the corpus

• ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, positive): “…growth and genomic instability and expression of growth factors (e.g., IGF1 and TGF-a), oncogenes, and tumor suppressor genes (Bindra et al., 2007; Bristow and Hill, 2008; Wilson and Hay, 2011); EMT, invasion, and metastasis (e.g., CXCR4, Snail, Lox, and cMET) (Finger and Giaccia, 2010;…”
• The DNA-damage response in human biology and disease (2009, background): “At later stages of cancer progression,chronichypoxiaand/orcyclesofhypoxiaandre-oxygenation mightalsocontributetogenomicinstabilityandderegulateDDR pathways 63 .”
• TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression (2010, background): “This very dynamic tumor microenvironment probably serves as a selective pressure for tumor cell variants through genomic instability, genomic heterogeneity and epigenetic alteration [65].”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “Furthermore, hypoxia downregulates DNA repair gene expression, and hypoxia/reoxygenation cycles can induce DNA strand breaks and oxidative base damage, gene amplifications, and DNA over-replication (Bristow & Hill, 2008).”
• Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “phosphorylation of p53 in the serine 15 region, thereby inhibiting the formation of p53–RPA70 complex [104].”
• Strategies to improve radiotherapy with targeted drugs (2011, background): “Hypoxia downregulates the expression of repair proteins and affects H”
• Regulation of cancer cell metabolism (2011, background): “Consequently, tumour hypoxia is a poor prognostic factor in a number of malignancie”