A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

By L. Sparks, Hui Xie, R. Koza, R. Mynatt, M. Hulver, G. Bray, Steven R Smith. Diabetes, 2005

658 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b18fb881e26fb97bab19589af0ecaa40d5e67fa8

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In Molecular Biology

1. M. Laplante
2. David M. Sabatini
3. Johan Auwerx
4. Markku Laakso
5. M. Hock
6. C. Palmeira
7. A. Kappas
8. Nader G. Abraham

In Physiology

1. Johan Auwerx
2. David M. Sabatini
3. M. Hock
4. A. Kralli
5. C. Palmeira
6. M. Yorek
7. A. Rolo
8. P. Puigserver

Citations in the corpus

• Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. (2006, background): “High-fat diet, which leads to insulin resistance due to increased concentrations of free fatty acids, downregulates PGC-1α mRNA and genes encoding proteins for complexes I, II, III, and IV (Sparks et al., 2005).”
• Pharmacological and Clinical Aspects of Heme Oxygenase (2008, positive): “Diabetic complications have been related to abnormalities in mitochondrial function (Shen et al., 2004; Hsieh et al., 2005; Sparks et al., 2005) as well as to increased endothelial cell death and detachment (Detaille et al.”
• Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, positive): “In humans, high-fat feeding results in downregulation of several genes associated with oxidative phosphorylation and mitochondrial biogenesis (298).”
• Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2011, background): “High-fat diets downregulate the genes related to mitochondrial biogenesis and the electron transport chain in muscle tissues from mice and humans (3, 40), suggesting that excess dietary fat impairs mitochondrial biogenesis and function.”
• mTOR signaling in growth control and disease (2012, positive): “Strangely, high-fat feeding, obesity, and type 2 diabetes, which are conditions associated with elevated mTORC1 activation, all impair mitochondrial biogenesis and function in muscles (Mootha et al., 2003; Patti et al., 2003; Sparks et al., 2005).”
• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006, background): “RSV’s effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC1a acetylation and an increase in PGC-1a activity.”
• Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease (2011, background): “Mitochondrial dysfunction has been reported in insulinresistant skeletal muscle as morphologic defects, decreased mitochondrial content, respiration, ATP synthesis, and TCA cycle turnover (Kelley et al., 2002; Petersen et al., 2004; Sparks et al., 2005).”
• Transcriptional control of mitochondrial biogenesis and function. (2009, background): “Lipid infusion or a highfat diet in humans leads to decreased expression of PGC-1α, PGC-1β, and their mitochondrial targets (171, 172).”