Functions of site-specific histone acetylation and deacetylation.

By M. Shahbazian, M. Grunstein. Annual Review of Biochemistry, 2007

1,641 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b14c893ab48d43276ef5c6a6d0c136e3b1213524

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Citations in the corpus

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes (2009, background): “Histone acetylation plays key roles in modulating chromatin structure and function (Shahbazian and Grunstein, 2007).”
Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes (2009, background): “Although, it is well established that HAT activity and increased histone acetylation correlate with increased gene transcription, the exact mechanisms promoting transcription are less clear (15).”
The many roles of histone deacetylases in development and physiology: implications for disease and therapy (2009, background): “This interferes with the generation of higher-order chromatin structures, and increasing the accessibility of transcription factors to their target gene”
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family (2012, background): “Cellular acetylation levels are stringently controlled by two enzyme families: the histone acetyltransferases (HATs) and histone deacetylases (HDACs) (Shahbazian and Grunstein, 2007).”
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “…of us have excitingly witnessed, the field has experienced an exponential growth in the past decade and is gradually reaching its maturity (Figure 2) (reviewed by Jenuwein and Allis, 2001; Lin and Dent, 2006; Goldberg et al., 2007; Kouzarides, 2007; Li et al., 2007; Shahbazian and Grunstein, 2007).”
The physics of epigenetics (2015, background): “Structural effects of H4K16 acetylation on chromatin compaction are also confirmed by the observation of a weakening of chromatin packing in vivo (Shahbazian and Grunstein, 2007) and are in general associated with actively transcribed genes (Taylor et al., 2013).”
Nucleosome positioning and gene regulation: advances through genomics (2009, background): “A detailed discussion of this subject is beyond the scope of this Review, but it is clear from a wide range of studies that histone acetylation is an important contributor to gene activatio”
Dynamic regulation of nucleosome positioning in the human genome. (2008, positive): “The covalent modifications of histones as well as the translational positioning of nucleosomes along the DNA have been implicated in profoundly influencing gene expression (reviewed in Berger, 2002; Henikoff et al., 2004; Kingston and Narlikar, 1999; Kouzarides, 2007; Li et al., 2007; Peterson and L”
Combinatorial patterns of histone acetylations and methylations in the human genome (2008, background): “Histones are subject to numerous covalent modifications, including methylation and acetylation, that occur mainly at their N-terminal tails and that can affect transcription of gene”
Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “Histone acetylation is associated with gene activation and histone deacetylation is associated with gene repressio”
Covalent modifications of histones during development and disease pathogenesis (2007, background): “It has been proposed that histone acetylation can alter histone-DNA interactions, creating a more open chromatin architectur”
Influence of Metabolism on Epigenetics and Disease (2013, positive): “Acetyl-CoA is also the substrate used by histone acetyl transferase (HAT) enzymes to modify histone tails as an integral determinant of the epigenetic state of chromatin in eukaryotic cells (Figure 1) (Lee and Workman, 2007; Shahbazian and Grunstein, 2007).”
The world of protein acetylation. (2016, background): “This applies especially to K5 and K12 in newly synthesized H4 and is more species-dependent for histone H3 [190,228].”