Nucleosome positioning and gene regulation: advances through genomics
By Cizhong Jiang, B. Franklin Pugh. Nature reviews genetics, 2009
1,098 citations recorded by the source corpus.
Knowing the precise locations of nucleosomes in a genome is key to understanding how genes are regulated. Recent 'next generation' ChIP–chip and ChIP–Seq technologies have accelerated our understanding of the basic principles of chromatin organization. Here we discuss what high-resolution genome-wide maps of nucleosome positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites, and how the composition and structure of promoter nucleosomes facilitate or inhibit transcription. A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/37deca13e33c5676b838a20743578b309f7ff67b
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In Molecular Biology
- P. Park
- Philipp Korber
- C. Peterson
- Shinya Watanabe
- B. Franklin Pugh
- Yajun Li
- Keith D. Robertson
- Bilian Jin
Citations in the corpus
- ChIP-Seq: advantages and challenges of a maturing technology (2009, background): “The combination of nucleosome positioning and dynamic modification of DNA and histones has a key role in gene regulatio”
- Genomic nucleosome organization reconstituted with pure proteins (2016, methodology): “The precise positioning and unique composition of nucleosomes at transcriptional start sites (TSSs) regulate gene expression (Jiang and Pugh, 2009b).”
- DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “Nucleosomes form the fundamental repeating unit of eukaryotic chromatin, serving as the basic module for DNA packaging that regulates the accessibility of DNA to interacting proteins and alters transcriptional states.(81) Recent studies have revealed that nucleosomal DNA is an important substrate fo”
- Latent enhancers activated by stimulation in differentiated cells. (2013, neutral): “Upon stimulation, nucleosomal occupancy was increased on both sides of a centrally located, H3-depleted area of the enhancer (Figures S4C and 4C), likely because of the barrier effect exerted by newly recruited TFs (Jiang and Pugh, 2009; Segal and Widom, 2009; Valouev et al., 2011).”