Post-transcriptional gene silencing by siRNAs and miRNAs.

By W. Filipowicz, Lukasz Jaskiewicz, F. Kolb, R. Pillai. Current Opinion in Structural Biology, 2005

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A MicroRNA Signature of Hypoxia (2006, background): “MicroRNAs represent approximately 1% to 2% of the eukaryotic transcriptome and have been shown to play critical roles in the coordination of cell differentiation, proliferation, death, and metabolism (1, 3, 6, 7, 17, 24) and more recently in tumorigenesis (2, 5, 6, 10, 13, 20, 21).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Humans have a single isoform of Dicer that functions in both the siRNA and miRNA pathways [108, 109].”
A human snoRNA with microRNA-like functions. (2008, background): “Small noncoding RNAs, including microRNAs (miRNAs), short interfering RNAs (siRNAs), and Piwi-interacting RNAs (piRNAs), are important regulators of gene expression (Filipowicz et al., 2005; Meister and Tuschl, 2004; Seto et al., 2007).”
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment (2008, unknown): “dtd" [ ]> miRNA populations, including mammalian homologues of lin-4 (mir-125) and let-7, undergo a marked transition during stem-cell differentiatio”
Small RNAs in transcriptional gene silencing and genome defence (2009, background): “Whereas the vast majority of miRNAs seem to act exclusively in the cytoplasm and mediate mRNA degradation or translational arres”