A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

By Agnieszka Rybak, Heiko Fuchs, L. Smirnova, C. Brandt, E. Pohl, Robert Nitsch, F. Wulczyn. Nature Cell Biology, 2008

835 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6cf870a772f954421119bda5310f5ce7d34b2d93

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In Cancer Research

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In Molecular Biology

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Citations in the corpus

• The widespread regulation of microRNA biogenesis, function and decay (2010, background): “Mature let-7 does not accumulate in undifferentiated embryonic stem cells (ESCs) and other progenitor cells, despite the high expression of the pri-let-7 transcript”
• The Lin28/let-7 axis regulates glucose metabolism (2011, background): “Another mechanism for let-7 downregulation involves the RNA-binding proteins Lin28a and Lin28b (collectively referred to as Lin28a/b), which are highly expressed during normal embryogenesis and upregulated in some cancers to potently and selectively block the maturation of let-7 (Heo et al., 2008; N”
• Non‐coding RNAs: regulators of disease (2010, background): “Likewise, the pluripotency factor LIN28 can bind to the conserved loop of the primary let-7 transcript (pri-let-7) to directly inhibit the Drosha cleavage steps [75–77] and can inhibit Dicer cleavage directly or by facilitating premiRNA degradation [78,79].”
• Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms (2011, neutral): “The developmentally regulated RNA-binding protein Lin28 was found to selectively repress expression of let-7 miRNAs (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008).”
• microRNAs in action: biogenesis, function and regulation (2023, background): “One of the first cases of regulated miRNA biogenesis regards the control of let-7 family maturation by Lin28 RBPs 114–117 (Fig.”
• Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. (2008, background): “, 2008) or Dicer processing of pre-let-7 (Rybak et al., 2008) in studies on mouse embryonic cells.”
• TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “, 2008) and Dicer processing of pre-let-7 (Heo et al., 2008; Rybak et al., 2008).”
• MicroRNAs in development and disease. (2011, background): “In agreement, it was found that lin-28 binds the loop structure of let-7 and inhibits its processing by both Drosha in the nucleus (448, 638) and Dicer in the cytoplasm (518).”
• Origins and Mechanisms of miRNAs and siRNAs (2009, background): “, 2008), as is Dicer-mediated cleavage (Heo et al., 2008; Rybak et al., 2008).”