Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.

By A. M. D. Urquiza, Suya Liu, M. Sjöberg, R. Zetterström, W. Griffiths, J. Sjövall, T. Perlmann. Science, 2000

774 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b06979705c334720c96e91c9c4330550b41e3c52

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Citations in the corpus

Essential fatty acids: biochemistry, physiology and pathology (2006, background): “DHA, thus released can activate RXR in neighboring cells, since DHA serves as ligand for RXR receptor [165, 166].”
Principles for modulation of the nuclear receptor superfamily (2004, background): “RXR heterodimers Numerous nuclear receptors bind to DNA as heterodimers with RXRs, which are believed to be cognate receptors for 9- cis retinoic acid (although evidence for alternative natural RXR ligands has recently been provide”
The promise of retinoids to fight against cancer (2001, background): “But they also have important physiological functions, particularly in the brai”
Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA (2015, background): “DHA is an endogenous ligand of RXRs (de Urquiza et al., 2000; Egea et al., 2002; Lengqvist et al., 2004) and aged rats treated with DHA show enhanced RXR expression (Dyall et al., 2010).”
Resolvins (2002, background): “However, it is not clear from the results of these studies (21, 51, 52) or of the many reported clinical trials whether DHA is precursor to potent bioactive structures that are responsible for the many reported properties attributed to DHA itself in regulating biological systems of interest.”
Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. (2009, neutral): “RXR [133].”