The promise of retinoids to fight against cancer

By L. Altucci, H. Gronemeyer. Nature Reviews. Cancer, 2001

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Signal integration by JNK and p38 MAPK pathways in cancer development (2009, background): “The JNK/JUN pathway regulates a plethora of target genes that contain AP1-binding sites, including genes that control the cell cycle, as well as survival and apoptosis, metalloproteinases and nuclear hormone receptors, such as retinoid receptor”
Principles for modulation of the nuclear receptor superfamily (2004, background): “Whether and how this distinct characteristic of RARβ is linked to its presumptive role as a tumour supressor remains to be established (see Ref”
Nuclear retinoid receptors and the transcription of retinoid-target genes. (2004, background): “The repressive effect of retinoids on AP-1 activity has been correlated with their antitumor activity and the importance of this cross-talk for growth control is increasingly recognized (Altucci and Gronemeyer, 2001b).”
AP-1: a double-edged sword in tumorigenesis (2003, background): “In at least some of these cases, the tumour-suppressive activity of retinoic acids is mediated by transrepression of AP-1 (Ref”