MicroRNAs direct rapid deadenylation of mRNA.

By Ligang Wu, Jihua Fan, J. Belasco. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,230 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b04ead52e59e2907494b2fb22e67e11415e2942e

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Citations in the corpus

Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “Arguments for either separate mechanisms of translational repression and mRNA destabilization (Wu et al., 2006; Fabian et al., 2009) or sequentially coupled repression and destabilization (Djuranovic et al., 2011) have been put forward and both are plausible.”
Getting to the root of miRNA-mediated gene silencing. (2008, background): “More recently, however, several reports showed that animal miRNAs do induce significant degradation of target mRNAs (Bagga et al., 2005; Wu and Belasco, 2005; Behm-Ansmant et al., 2006; Giraldez et al., 2006; Wu et al., 2006; Chendrimada et al., 2007; Eulalio et al., 2007a).”
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (2006, background): “…silence gene expression in a GW182-dependent manner Previous studies indicate that miRNAs can reduce the levels of the targeted transcripts, and not just the expression of the translated protein (Bagga et al. 2005, Lim et al. 2005; Giraldez et al. 2006; Rehwinkel et al. 2006; Wu et al. 2006).”
Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation (2007, background): “…induction of translation inhibi- tion, which can also be associated with transcript destabiliza- tion (Bagga et al, 2005; Giraldez et al, 2006; Wu et al, 2006). miRNAs have been found to be implicated in a large variety of cellular processes, and their aberrant expression has been linked…”
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock1 (2007, background): “outputs specific for each of these inflammatory stimuli (43, 48, 49).”
Origins and Mechanisms of miRNAs and siRNAs (2009, background): “However, for some miRNA-target interactions, there is a signiﬁ-cant reduction in mRNA abundance due to an increase in mRNA degradation (Bagga et al., 2005; Lim et al., 2005; Behm-Ansmant et al., 2006; Giraldez et al., 2006; Wu et al., 2006).”
THE MECHANISM OF EUKARYOTIC TRANSLATION INITIATION AND PRINCIPLES OF ITS REGULATION (2010, background): “This cannot be the complete answer, however, as translation of mRNAs that lack poly(A) tails can also be repressed by miRNA”