Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation

By Carlos le Sage, Remco Nagel, D. Egan, Mariette Schrier, Elly M. Mesman, A. Mangiola, C. Anile, G. Maira, N. Mercatelli, S. Ciafrè and 2 more. 2007

754 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2ffe0892f9465eb93b4ec300677ac64091243ec9

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Citations in the corpus

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. (2007, methodology): “Using functional genetic-screening approaches, we have recently identified the miRNA-mRNA interactions between p27 and miR-221 and between LATS2 and miR-372 as promoting cancer (le Sage et al., 2007; Voorhoeve et al., 2006).”
CDK inhibitors: cell cycle regulators and beyond. (2008, positive): “In addition, the inhibition of p27 expression by miRNAs in glioblastomas and prostate carcinoma cell lines was recently described, and this might constitute yet another way to decrease p27 levels in tumors (Galardi et al., 2007; le Sage et al., 2007).”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “However, the contribution of miRNAs to the tumorigenic capacity of SRSF1 is uncertai”
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. (2008, background): “Transfection with miR-7 inhibited normalizedactivity of the EGFR 3 ¶-UTR reporter by f83% (P 16 ).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Contrary to increasing cell death, miR-221 and miR-222 were shown to directly target p27Kip1 in a prostate tumor cell line model, resulting in proliferation and increased oncogenesis (Galardi et al., 2007; Gillies and Lorimer, 2007; le Sage et al., 2007).”
MicroRNA and cancer (2012, background): “Elevated levels ofmiR-221 andmiR-222 are required in various cancers to inhibit the expression of p27 and stimulate cell proliferation (le Sage et al., 2007) and PUM1 is also mutated in some cancers (COSMIC database, Wellcome Trust Sanger Institute) where it may facilitate this negative regulation…”
microRNAs in cancer (2013, background): “Elevated miR-221 and miR-222 expression is linked not only to proliferation (140) and migration (139) but also to apoptosis (141).”
Silencing of microRNA families by seed-targeting tiny LNAs (2011, background): “The miR-221/222 family consists of two members that negatively regulate the cell-cycle inhibitor p27 Kip1 through two target sites in its 3′ UT”