Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

By J. Rothbard, Sarah B. Garlington, Q. Lin, T. Kirschberg, Erik Kreider, P. Mcgrane, P. Wender, P. Khavari. Nature Medicine, 2000

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. (2002, background): “This finding suggests that a conformational peptides across the plasma membrane (Rothbard et al., 2000). change takes place in either BCL-2 and/or a BH3 peptide upon r8BIDBH3 was capable of killing Jurkat leukemic cells, whereas binding.”
Cell-Penetrating Peptides: From Basic Research to Clinics. (2017, background): “However, this problem was overcome by conjugating CsA to a polyarginine [114].”