Repression of protein synthesis by miRNAs: how many mechanisms?
By R. Pillai, S. Bhattacharyya, W. Filipowicz. Trends in Cell Biology, 2007
1,193 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/af7d0e9b3791b601fc1edb4391fe8d7ee0b4199d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- E. Olson
- Eva van Rooij
- Sam Griffiths-Jones
- P. Murphy
- Leigh-Ann MacFarlane
- Frank J. Slack
- Nikolaus Rajewsky
- Anton J. Enright
In Molecular Biology
- E. Olson
- Eva van Rooij
- Sam Griffiths-Jones
- P. Murphy
- Leigh-Ann MacFarlane
- Frank J. Slack
- Nikolaus Rajewsky
- Stijn van Dongen
Citations in the corpus
- A human snoRNA with microRNA-like functions. (2008, background): “…al., 2007). miRNAs and siRNAs guide sequence-specific cleavage, deadenylation, or translational repression of target mRNAs (Chen and Rajewsky, 2007; Pillai et al., 2007). piRNAs are specifically expressed in testes (Seto et al., 2007) and control retrotransposition in the mammalian germ line…”
- MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “miRNAs constitute a class of short, noncoding RNAs that posttranscriptionally regulate gene expression in multicellular organisms by interaction with partially complementary target sites in mRNAs (Pillai et al., 2007).”
- Small non-coding RNAs in animal development (2008, background): “Various mechanisms have been documented, including translational inhibition at the level of initiation and elongation, rapid degradation of the nascent peptide, mRNA sequestration into P bodies and mRNA degradation (reviewed in Ref”
- miRBase: tools for microRNA genomics (2007, background): “…from longer transcripts encoded in animal, plant and virus genomes, and recently discovered in a single-celled eukaryote (1,2). miRNAs regulate the expression of target genes by binding to complementary sites in their transcripts to cause translational repression or transcript degradation (3).”
- Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “In thismodel, the nascent polypeptide is degraded by protease activities [78] (Figure 1(g)).”
- The Effects of Cadmium Toxicity (2020, background): “MiRNA’s main function is to down-regulate gene expression by interfering with messenger RNA (mRNA) functions [117,118].”
- miRecords: an integrated resource for microRNA–target interactions (2008, background): “(5,6)], suggesting that miRNAs could induce translation repression at both the initiation phase and the elongation phase of translation.”