Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.
By A. Takagi, A. Hirose, T. Nishimura, N. Fukumori, A. Ogata, N. Ohashi, S. Kitajima, J. Kanno. Journal of Toxicological Sciences, 2008
793 citations recorded by the source corpus.
Subfields: Immunology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/af6b94d5a04dcf5ab8fb3d0c30079d6e6868b86b
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In Immunology
Citations in the corpus
- In vitro assessments of nanomaterial toxicity (2009, background): “Other common transformed epithelial lines include MDCK (kidney), HT-1080, HT29-18-C1 (colonic), and HeLa (cervical) [11].”
- Occupational exposure limits for nanomaterials: state of the art (2010, background): “Although results from animal studies of CNT do not provide specific information on the relationship between fiber dimension and response, it appears exposure to CNTs can elicit responses that are similar to asbestos fibers (Poland et al. 2008; Takagi et al. 2008; Drew et al. 2009; Jaurand et al. 2”
- NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Furthermore, recent publications have demonstrated that MWCNT not only induce an asbestos-like inflammatory response and the formation of granulomas in vivo following intraperitoneal administration [142], but also promote the development of mesothelioma in more long-term in vivo studies following th”
- Effects of nanomaterial physicochemical properties on in vivo toxicity (2009, positive): “Recently, studies have indicated that CNT responses are similar to the carcinogenic responses of asbestos fibers when injected into the peritoneal cavity [61,62].”
- Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “Studies in mice have shown that frustrated phagocytosis can lead to massive release of oxygen radicals by immune cells, which can result in chronic granulomatous inflammation and potentially mesothelioma if the CNTs are in the pleural cavity or peritoneum [209].”
- Techniques for physicochemical characterization of nanomaterials (2013, background): “Furthermore, recent studies demonstrated an asbestos-like pathogenic responsewhen carbonnanotubes of length greater than 20 μm were delivered into the abdominal cavity of mice (Kostarelos, 2008; Poland et al., 2008; Powers et al., 2009; Takagi et al., 2008).”
- The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles (2012, neutral): “It is also generally accepted that fiber-shaped NPs of a given material are more reactive and toxic compared with spherical particles: carbon nanotubes, for instance, are generally more toxic than fullerenes.(26,27) Hydrophobicity is often linked to surface charge, but at the same surface charge, NP”
- Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. (2009, background): “There is evidence based on some toxicological studies that prolonged accumulation of long (>10 μm), rigid, pristine nanotubes in tissues may be associated with health risks such as carcinogenesis and should be avoide”