In vitro assessments of nanomaterial toxicity
By Clinton F. Jones, D. Grainger. Advanced Drug Delivery Reviews, 2009
551 citations recorded by the source corpus.
Nanotechnology has grown from a scientific interest to a major industry with both commodity and specialty nanomaterial exposure to global populations and ecosystems. Sub-micron materials are currently used in a wide variety of consumer products and in clinical trials as drug delivery carriers and imaging agents. Due to the expected growth in this field and the increasing public exposure to nanomaterials, both from intentional administration and inadvertent contact, improved characterization and reliable toxicity screening tools are required for new and existing nanomaterials. This review discusses current methodologies used to assess nanomaterial physicochemical properties and their in vitro effects. Current methods lack the desired sensitivity, reliability, correlation and sophistication to provide more than limited, often equivocal, pieces of the overall nanomaterial performance parameter space, particularly in realistic physiological or environmental models containing cells, proteins and solutes. Therefore, improved physicochemical nanomaterial assays are needed to provide accurate exposure risk assessments and genuine predictions of in vivo behavior and therapeutic value. Simpler model nanomaterial systems in buffer do not accurately duplicate this complexity or predict in vivo behavior. A diverse portfolio of complementary material characterization tools and bioassays are required to validate nanomaterial properties in physiology.
Subfields: Biomaterials, Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/ee254a9f7a712303a9de69c636ce6773554c6f23
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Citations in the corpus
- Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. (2012, background): “Additionally, there is a recognized need for development and validation of nano-toxicity characterization methods for obtaining reliable predictive safety information [11].”
- Cellulose nanofibers produced from banana peel by chemical and mechanical treatments: Characterization and cytotoxicity assessment (2018, methodology): “Although nanoparticles have beneficial effects, they may endanger the human health, so possible risks should be evaluated (Jones & Grainger, 2009).”
- Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays (2012, methodology): “As a result, it has been recommended that a diverse portfolio of cell viability and cytotoxicity assays (including the Alamar Blue assay) with different chemistries and detection mechanisms should be used for the assessment of nanoparticles or nanomaterials [74,75].”