Interactions of nanomaterials and biological systems: implications to personalized nanomedicine

By Xue-Qing Zhang, Xiaoyang Xu, N. Bertrand, Eric M. Pridgen, A. Swami, O. Farokhzad. Advanced Drug Delivery Reviews, 2012

406 citations recorded by the source corpus.

The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to design flexibility, small sizes, large surface-to-volume ratio, and ease of surface modification with multivalent ligands to increase avidity for target molecules. Nanomaterials can be engineered to interact with specific biological components, allowing them to benefit from the insights provided by personalized medicine techniques. To tailor these interactions, a comprehensive knowledge of how nanomaterials interact with biological systems is critical. Herein, we discuss how the interactions of nanomaterials with biological systems can guide their design for diagnostic, imaging and drug delivery purposes. A general overview of nanomaterials under investigation is provided with an emphasis on systems that have reached clinical trials. Finally, considerations for the development of personalized nanomedicines are summarized such as the potential toxicity, scientific and technical challenges in fabricating them, and regulatory and ethical issues raised by the utilization of nanomaterials.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f106b70ef57fe6c261ada67ef7af418745fd94d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. N. Bertrand
2. N. Kamaly
3. Xiaoyang Xu
4. Jun Wu
5. O. Farokhzad

In Biomedical Engineering

1. N. Bertrand
2. Xiaoyang Xu
3. N. Kamaly
4. Jun Wu
5. O. Farokhzad
6. R. Singh
7. J. Knowles
8. M. AlQaysi

In Molecular Biology

1. N. Bertrand
2. N. Kamaly
3. Xiaoyang Xu
4. Jun Wu
5. O. Farokhzad

Citations in the corpus

• Sol-gel based materials for biomedical applications (2016, background): “Ligands can be selected or engineered to target over-expressed receptors on healthy and diseased cells [397].”
• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “Meaningful exploitation of the EPR effect in humans will require precise understanding and control of the physicochemical properties of nanomaterials [134] and, possibly artificial fine tuning of the tumor microenvironment [28].”