Effects of nanomaterial physicochemical properties on in vivo toxicity
By Kristin L. Aillon, Yumei Xie, N. El-gendy, C. Berkland, M. Forrest. Advanced Drug Delivery Reviews, 2009
753 citations recorded by the source corpus.
It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological interactions. However, most in vivo toxicity concerns focus primarily on pulmonary, oral, and dermal exposure to ultrafine particles. As nanomaterials expand as therapeutics and as diagnostic tools, parenteral administration of engineered nanomaterials should also be recognized as a critical aspect for toxicity consideration. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Here, the physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed.
Subfields: Biomedical Engineering, Materials Chemistry, Polymers and Plastics
View Paper: https://www.semanticscholar.org/paper/8177f4634519e074e3cd89b16324c1437a6ec57d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
In Materials Chemistry
In Polymers and Plastics
Citations in the corpus
- Nanoparticles as Adsorbent; A Positive Approach for Removal of Noxious Metal Ions: A Review (2015, background): “Salient approach of nanomaterials as adsorbent Specific features of oxide and carbon based nanomaterials: Oxide and carbon based nano-adsorbents are most effectual and cost-effective for the rapid removal and recovery of metal ions from wastewater effluents due to their large surface area and optima”
- Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations (2014, neutral): “including endocytosis, cellular uptake, and efficiency of particle processing in the endocytic pathway are dependent on size of the material [12, 16].”
- The nanosilica hazard: another variable entity (2010, neutral): “logical research towards nanoparticles [89-94].”
- Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota (2015, neutral): “However, it is important to note that many in vivo studies with higher-level organisms often give mixed results on toxicity (Aillon et al. , 2009; Chen et al. , 2009; Khlebtsov and Dykman, 2011).”
- Silver Nanoparticles as Potential Antiviral Agents (2011, background): “, NFκB), activator protein-1, and kinases involved in inflammation [94,95,96,97].”