The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.

By E. Tian, F. Zhan, R. Walker, E. Rasmussen, Yupo Ma, B. Barlogie, J. Shaughnessy. New England Journal of Medicine, 2003

1,507 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/aedf452469b3babc395a7d3071eee564eff7e4f5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Hans Clevers
2. S. Rajkumar
3. J. Adams

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. J. Smolen
5. P. Richardson
6. T. Hideshima
7. W. Kuehl
8. D. Lacey

In Oncology

1. R. Nusse
2. J. Smolen
3. Hans Clevers
4. D. Lacey
5. Georg Schett
6. K. Redlich
7. J. Adams
8. S. Rajkumar

Citations in the corpus

• Dickkopf-1 is a master regulator of joint remodeling (2007, background): “Recently, aberrant expression of DKK-1 in myeloma cells was shown to be associated with increased bone erosions in human multiple myelom”
• Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “but readily secreted by cytokine-activated or malignant cell”
• Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. (2005, background): “Specifically, Specht et al18 analyzed formalin-fixed, paraffin-imbedded blocks of MM tumor cells and showed that 11 (23%) of 48 of tumors expressed high levels of cyclin D1 RNA and had t(11;14) translocations (similar to our 11q group); whereas 15 (31%) of 48 of samples expressed low to intermediate”
• Wnt/β-catenin signaling and disease. (2012, positive): “In addition, local DKK1 production by malignant plasma cells induces osteolytic bone lesions and pathological fractures, a major complication in multiple myeloma (Tian et al., 2003).”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “While hypermethylation of human DKK3 correlates with Table 2 Dkk gene deregulation in cancer Dkk Cancer or tumor cell line Dkk1 Myeloma m Tian et al. (2003) Colorectal cancer k Gonzalez-Sancho et al. (2005); Aguilera et al. (2006) Hepatoblastomas m Wirths et al. (2003) Wilm’s tumor m Wirths et al.…”
• Osteoblasts in prostate cancer metastasis to bone (2005, background): “gov/cancertopics/pdq/treatment/myeloma/healthprofessional">multiple myeloma , WNT signalling is inhibited by the expression of the WNT antagonist DKK1 (Ref”
• Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets (2007, background): “Importantly, recombinant human DKK1 or bone marrow plasma containing increased levels of DKK1 inhibits the differentiation of osteoblast precursor cells in vitro”