A three-dimensional view of the molecular machinery of RNA interference

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CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation. (2011, background): “Yet, with the discovery of RNA interference (RNAi) in eukaryotes and the ever-expanding repertoire of roles of small noncoding RNAs in eukaryotes, it has become obvious that small RNAs can be multifunctional and versatile (29, 55, 61).”
Pollutants inducing epigenetic changes and diseases (2019, background): “They are single-stranded RNA which has major functions in RNAi (RNA interference) (Jinek and Doudna 2008) and post-transcriptional modifications (Cai et al.”
Molecular mechanisms of RNA interference (2013, neutral): “Eventually such miRNAs were found to be widespread: As much as 5% of the human genome is dedicated to encoding and producing the >1,000 miRNAs that regulate at least 30% of our genes (38, 58).”
Mechanisms of dsRNA uptake in insects and potential of RNAi for pest control: a review. (2010, methodology): “For more details on cell-autonomous RNAi machinery, we suggest the following reviews: Meister and Tuschl (2004), Fire (2007), Jinek and Doudna (2009) and Siomi and Siomi (2009).”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “These properties explain why the nucleotide at the miRNA position 1 does not need to base-pair to the target and why perfect complementarity in the seed sequence is crucial for nucleating the miRNA-mRNA interaction (41, 57, 58).”